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Chloride (Cl-) is inert and non-toxic. However, chloride levels are used as a measure of salinity. Sea water, for example, has 19,353 ppm chloride, and freshwater typically contains less than 100 ppm.

Those species that require < 20 ppm Cl- simply require water with very low TDS. Salinity tolerance is expressed in chloride levels because, at one time, chloride was the easiest to measure. There are better methods now.

Sulfate (SO4) is also inert and harmless at low levels. Sea water contains 2,712 ppm sulfate and freshwater typically contains less than 80 ppm.
 
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