I have two batches of Purigen in two separate bags (Seachem's "The Bag" product is the best, I think, despite the price). I have one batch in the canister and leave a fresh one in storage so that I can do a quick swap if my water seems to need it, or whenever my usual canister cleaning cycle comes 'round. My regeneration process lasts 2 days, but with two batches my tank never goes without.
I really like having the ability to put a fresh batch in at the first sign of cloudiness.
Will