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I've used the wafers for over a year as well for: pleco, cories, and shrimp. No one has had issues that can be correlated with feeding the wafer. I'd do as mentioned above and contact Hikari and ask about a bad batch, they will tell you what to look for on the bag to give them a # they'd need to cross reference if its the case. The only other thing I can think of is if you have an unfinished cycle and leaving the wafers in for a long time is spiking ammonia or nitrite and that kills the loaches. However if you put an equal proportion of flake food in it should have the same effect...
 
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