No. Home Depo acrylic will not do the trick. Local home improvement stores carry extruded acrylic. For a small tank such as a 2-5g maybe but I still wouldn't trust it. The psi holding capacity just isn't there. What you want is cel cast for aquariums. The taller the tank, the thicker the acrylic needs to be. Not the wider or the longer. Pressure comes from the height of the water column.