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Here is a link to a forum dedicated to Puffers. Lots of great info and really helpful members. You could add charcoal to the filter if you think the fertilizer might be the problem. I have squirted fertilizer right on fish, not trying to they just swam into the stream, and never had one show a problem. Check with the people over at the puffer sight to see if you can use salt just in case it is an infection or a parasite.