Ei requires the water change each week of 50% or more to eliminate doubling of nutrients. The premise is that dosing to these levels so they never go beyond double the concentrations will not lead to deficiencies or toxicities. Going way past that (not sure of the concentration of your 50 ml dose) is not recommended as you could run into problems from too many nutrients in the tank. It is a waste either way because the plants would not consume any where near the amount being dosed.
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