Yes actually you can run with just about any regulator that can bring the pressure down to about 10 PSI. You will just have to get a different nipple for the hose size and get a needle valve. Also a reactor or diffusion unit for actually getting the CO2 dissolved in the water. I almost forgot a bubble counter.I just bought a CO2 tank attached with a regulator for soda machine and was wondering if I can convert this to a planted tank? The only problem I have is that I have some pretty expensive fish that I do not want to kill. Has anyone tried converting this with success? If converting this CO2 regulator will be more than $50 dollars or more, I would rather just buy a JBJ regulator. Any suggestions would be great!