It really doesn't take much IMO to move dissolved co2/nutrients around most aquariums. So having intake/outake on opposite sides as well same side will work on most normal sized aquariums.
Between all the plants, hardscape, prefilters (for shrimp), etc. most solid waste isn't making it into the filter regardless. That's the beauty of the plants and waterchanges. The plants can process the decay almost immediately and the water changes are usually weekly. When wastes goes into the filter it's still part of the system, releasing ammonia and other toxins. There's nothing magical going on in there. It's far more important as a flow device. There's a reason heavily planted tanks stay clean and algae free while tanks with no or limited plant mass even with the largest filters do not. IMO of course.
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