I use a full wet/dry on my 100gallon, I go through a 10lb CO2 every 3-4 months at high CO2 levels, 30-40ppm. I don't care about the additional CO2 loss, it is cheap to refill.
So no, it won't affect your CO2 levels if you have effective Co2 reactor, you just have to use a little higher bubble rate.
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Flourite, wet/dry, AHSupply 302w PC, PinPoint controller
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15w T6+15w T8
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40w T6 ODNO4x, no CO2. Discus grow out.
10gallon Tonina tank, 2x15w T6 ODNO 4x
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I will do aquascapes after I collect all the plant species and grow them to perfection.