Plenty strong enough. There are builds all over the place and I believe reef central has a pretty detailed thread dedicated to instructions. Google a DIY aquarium stand and you'll find it. Also, Joey, TheKingOfDIY on YouTube has some pretty informative videos on stand building. They are all 2x4s. The only time I would deviate from the 2x4 build is to put 2x6 or 2x8s around the top to span longer than 4'.
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