I do agree that using a sand substrate over any type of other substrate can prove to be very high maintenance. But using good quality, larger-grained, higher density PFS by itself can be very satisfactory from the standpoint of appearance, facility to keep clean (no detritus, uneaten fish food, etc. gets down under and into the sand, unless you turn it over and put it there yourself), is much more conducive to the well-being of bottom-dwellers like Cories, or shrimp, e.g.; it doesn't get siphoned out when vacuuming, like play sand does, and does not free-float when disturbed, to get into filters and clog up impellers.
And, if the sand depth is maintained at under 3", there is very little likelihood of anaerobic pockets developing.
As for white sand (as opposed to dark, or black) - one tends to pay more attention to cleansing to keep it looking good, whereas with black (which of course doesn't show the dirt as much) the tendency may be to get lazy, and not clean it as often (cause you can't see the crud) - to me that's an incentive to 'go white'.
And many plants grow very well in it, using root tab ferts.
As for maintaining it's fresh, new, clean look - that's easily done by removing (siphoning out) the top 20% layer of sand roughly every 6 months or so, and replacing that with new sand - no problem - stays looking like it's right out of the bag!
to Mxx: Your thoughts of placing a white band (tape) around the outside bottom of the tank, if using white PFS, is a good one - especially if you're leery about scratching the glass by getting down into the sand with a scraper to remove algae, etc.
And btw, PFS is completely inert - it does not leach silicates.
For what it's worth, here's my tank with quartz-based white silica PFS as substrate.
The sand had been in the tank for about a year when the pics were taken, and I had replaced the top layer of sand only once during that time, about 3-4 months before the pics were taken. The same sand looks just as good today as it did then.