The larger screen makes it a little difficult to get in and properly mist but other than that not an issue. As far as the larger tanks are concerned the only issue I see is door size, it would be huge and come out really far due to the forward opening door. If you were able to find a way to make it open from the side that would solve the problem. I feel the weight of the door might be an issue as well. I built a vert conversion for a 10g for a friend of mine and he dropped the door and it shattered.