Mine runs all the time into the inlet of my 2213. At 1 bubble per second, I don't have any problems with airlock, I only get occasional bubbles out the spraybar in the late afternoon, and my nighttime pH drop is no more than 0.2 units. With all the floss in the canister, the CO2 has plenty of time to dissolve.
72g bowfront planted, CO2, 4x - T5HO, Eheim 2213 and 2217, 2 angels, pristella tetras, blue tetras, betta, albino bristlenose pleco, albino cories. Sword, vals, hygros, ludwigias, java moss and fern, anubias
2g Mac-quarium. Clown gravel, fluorescent plastic plants, and 2 guppies.