I have a Fluval 406 hooked up to the bulkheads on a 60 gallon cube and have had no issues so far. The holes are drilled in the bottom of mine.
I don't really understand the issue people continually bring up of the excessive pressure on the canister filter. Hydrostatic pressure is based on the height, the volume of water does not affect the pressure.
In a typical canister filter the tuning goes over the edge of an aquarium. After the siphon has broken the water pressure would be greater than a canister plumbed into a bulkhead as the height of the water column would be greater in the traditional canister setup.
I understand the concern of a failure and draining the water level down to the lowest bulkhead, but this would happen in a traditional setup to the siphon break point as well