How are you cleaning the filter, glass, décor etc? What are your actual water parameters (Temp, PH, ammonia, nitrite, nitrate)? do you have a picture of the tank? is it planted?
Prime will not remove ammonia but rather convert it to less toxic ammonium (for approx. 48hrs). Our test kits test for both and depending on your PH and temps ammonia may or may not be an issue depending on the level of ammonia you have.