The reason for not doing routine big water changes on non-CO2 tanks is that tap water often contains a lot of dissolved CO2. When you do a water change you are adding lots of CO2 to the tank, which soon escapes from the water surface, but it does give the fluctuating CO2 that can trigger algae to start growing.
Compared to oxygen or nitrogen, CO2 dissolves very easily into water in high concentrations, so I would expect typical tap water to have lots of CO2 but not much O2 or N2. That surge in CO2 is likely to be the cause of the pearling after a water change. That also suggests that you don't have enough CO2 in the water before doing the water change, or you would have pearling before the water change.