Try it out but generally, silicone will eventually peel away from plastics. It's too smooth like teflon.
Glass is just as smooth. Glass needs silicone as acrylic need solvents. I doubt if roughing up acrylic would do much. Silicone will stick to acrylic but it won't be a strong bond my any means. One of two things will happen. It will eventually fail or it can be easily pulled apart, which ever happens first.