Yes, but that doesn't help the person who has 'let the tank go' and is trying to re-set it rather than tear it all down and start from scratch. But your point is well taken.
I'd be curious to know whether most of the people who did this protocol and didn't experience widespread livestock death had 'relatively' larger tanks.
I think the expression 'an ounce of prevention is worth more than a pound of cure' applies here. It's pretty obviously that this treatment will have different effects on each person's tank depending on the different parameters, etc. So your kinda rolling the dice, not really knowing how it will turn out. How do you control for all those variables? you can't. Being pro-active and over-killing organic removal and other maintenance habiats from the getgo is your best bet, instead of relying on dosing chemicals with unknown effects on your livestock.