Planted Tank Guru
Join Date: Jan 2010
Location: Contra Costa CA
Whatever tool you decide on, clamp a guide to the acrylic so you can stabilize the tool and cut a straight line. This guide could be a straight piece of wood (perhaps a scrap of 1 x 4) or a level (though I do not like to use my levels like this).
If Dremel has some special blades for plastic, use them.
I have not done this, but I have watched my son, and seen the results- he cut some really interesting acrylic computer cases then back lit them.
When I cut acrylic I used a skil saw with a plywood blade. I have drilled, too, using a wood bit, and turned the drill to its lowest setting.