I can only try to give you my experience with the 20" tall unit on a 40b. I run a Mag 7 through it with 3/4" lines, and have it choked back to probably half flow with a ball valve. I put a scrubby in the filter body to reduce the tiny bubbles in the tank, and I have the output going to a spray bar on the opposite side of the tank from the main filter intake, where I also monitor pH with a drop checker. On a 150g tank I would think it could work but I would definitely recommend that you NOT put it on your filter returns. That makes it difficult to control the flow through the unit and restricts your options accordingly. You might want to consider a sump for a tank that big. That would cut down or eliminate the Seven-Up bubbles in the tank issue. You would seal off the sump in a way that doesn't allow the CO2 to escape. If I'm not mistaken I think that's how Tom Barr does it (plantbrain).